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Aggressive variants of prostate cancer - Are we ready to apply specific treatment right now? Cancer Treat Rev. In most cases, prostate cancer essentially depends on androgen receptor signaling axis, even in castration-resistant setting, and hence may be targeted by second generation hormonal therapy. However, a subset of patients bears androgen-independent cancer biology with a short-term response to hormonal treatment, early and extensive visceral metastases, low PSA levels and poor outcomes.

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Neuroendocrine transdifferentiation of prostate carcinoma cells and its neuroendocrine cancer history significance Madalina Marcu, E. Radu, Maria Sajin Neuroendocrine NE cells are a distinct epithelial cell compartment of the normal human prostate gland. Their phenotype and range of endocrine secretion products are similar, but not identical to those of NE-like cells from prostate carcinoma. Neuroendocrine differentiation NED is a feature commonly seen in prostate carcinoma and a number of studies pointed out that its extent is associated to hormone therapy refractory and aggressive disease.

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This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving the therapy.

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