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Usually, water quality decreases in the drinking water distribution systems due to unwanted physical, chemical and biochemical reactions occurring in the distribution systems. The variation of the main physicochemical parameters of drinking water such peritoneal cancer index calculation turbidity, pH, oxidability, chlorides and free residual chlorine concentration, conductivity, iron content, water hardness and nitrates concentrations was studied. The drinking water samples were collected weekly during the year from 16 fixed points of the distribution network of Satu Mare.