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Research Links Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression metastatic cancer bone other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers. The ultimate goal is to identify and validate targets for combination therapy with radiation and immunotherapy in preclinical studies, and in parallel conduct whitewash exe of biomarkers of response in correlative clinical studies. He has been invited to present his results at over local, national and international meetings, including Grand Rounds, Plenary Talks and Keynote Lectures.

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Managing Bone Metastases in Prostate Cancer susținută de paraziți ai pământului diatomac

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Rezumat Tesutul osos reprezinta un micromediu hypoxic capabil sa potenteze metastazele tumorale si cresterea acestora. Aceasta lucrare este o trecere in revista a datelor din literatura privind mecanismele moleculare ale hipoxiei ca unul dintre contributorii majori ai metastazelor tumorale osoase, care regleaza produsii de secretie cu rol in influentarea proliferarii si a raspandirii celulelor tumorale. Cuvinte-cheie: hypoxia, remodelarea osoasa, metastaze tumorale Abstract Bone tissue is a hypoxic microenvironment capable of metastatic cancer bone tumor metastasis and growth. This paper is a review of literature data on molecular mechanisms of hypoxia as one of the major contributors to tumor bone metastasis, regulating metastatic cancer bone products that drive tumor-cell proliferation and spread.

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The patient initially received palliative chemotherapy with Paclitaxel, discontinued due to allergic reactions, and targeted therapy with Herceptin. BM were treated with antalgic radiotherapy and bisphosphonates.